反応 #2186191

反応方程式

4-[4-(2-Fluoro-ethyl)-piperazin-1-yl]-2-hydroxy-benzaldehyde

benzothiazol-2-yl-acetic acid methyl ester

piperidine

→

desired product

収率 55.0%

3-Benzothiazol-2-yl-7-[4-(2-fluoro-ethyl)-piperazin-1-yl]-chromen-2-one

収率 55.0%

溶媒

benzene

acetonitrile

反応条件

後処理

1. 1
   その他to reach room temperature
2. 2
   ろ過the precipitate filtered off
3. 3
   洗浄washed with diethylether
4. 4
   その他dried under high vacuum

実験手順

200 mg (0.793 mmol) 4-[4-(2-Fluoro-ethyl)-piperazin-1-yl]-2-hydroxy-benzaldehyde and 164 mg (1 eq.) benzothiazol-2-yl-acetic acid methyl ester are heated to reflux for 3 h in 5 mL benzene and 2.5 mL acetonitrile, in the presence of 0.157 mL (2 eq.) piperidine. The reaction mixture is allowed to reach room temperature and the precipitate filtered off, washed with diethylether and dried under high vacuum to yield 90 mg (55%) of desired product as a yellow powder (melting point: 246° C.).

出典