反応 #2186186

反応方程式

9-borabicyclo[3.3.1]-nonane

4-bromo-3,3,4,4-tetrafluoro-1-butene

borane

hydrogen peroxide

sodium hydroxide

→

4-bromo-3,3,4,4-tetrafluorobutanol

溶媒

tetrahydrofuran

n-hexane

反応条件

実験手順

Also, the sulfonic acid salt of formula (1) can be synthesized by starting with 4-bromo-3,3,4,4-tetrafluoro-1-butene which is readily available in the industry, effecting hydroboration with a borane such as 9-borabicyclo[3.3.1]-nonane (9-BBN) in a solvent such as n-hexane or tetrahydrofuran by a standard technique, treating the product with an oxidizing agent such as aqueous hydrogen peroxide in the presence of a base such as sodium hydroxide to form 4-bromo-3,3,4,4-tetrafluorobutanol, and esterifying it with carboxylic halide in the presence of a base such as triethylamine.

出典