反応 #2186180

反応方程式

compound ( b5 )

3-chloro-2-fluorophenol

sodium hydroxide

diethyl sulfate

→

1-chloro-3-ethoxy-2-fluorobenzene

反応条件

後処理

1. 1
   workup.WAITover 1 hour in a temperature range of 25 to 35° C.
2. 2
   その他The resulting organic layer was collected
3. 3
   洗浄washed with 200 mL of water in three times
4. 4
   その他by drying

実験手順

The compound (b5) was added dropwise to a reactor having 1,200 g of a 10% sodium hydroxide aqueous solution placed therein over 30 minutes in a temperature range of 20 to 40° C. Thereafter, 462 g of diethyl sulfate was added dropwise thereto over 1 hour in a temperature range of 25 to 35° C., followed by stirring for 5 hours in that temperature range. The resulting organic layer was collected and washed with 200 mL of water in three times, followed by drying, to obtain 505 g of 1-chloro-3-ethoxy-2-fluorobenzene (b44). The resulting liquid was colorless.

出典