反応 #2186178

反応方程式

compound ( b43 )

2-chloro-1-ethoxy-3-fluorobenzene

bromine

→

1-bromo-3-chloro-4-ethoxy-2-fluorobenzene

収率 86.4%

反応条件

後処理

1. 1
   workup.ADDITIONwas added dropwise over 1 hour in a temperature range of 20 to 40° C.
2. 2
   その他The resulting reaction mixture
3. 3
   洗浄was washed with a saturated sodium thiosulfate aqueous solution
4. 4
   その他The resulting reaction mixture
5. 5
   洗浄having been washed
6. 6
   workup.DISTILLATIONwas subjected to fractional distillation under reduced pressure

実験手順

606 g of the compound (b43) was added to a reactor in a nitrogen atmosphere, to which 570 g of bromine was added dropwise over 1 hour in a temperature range of 20 to 40° C., followed by stirring for 30 minutes. The resulting reaction mixture was washed with a saturated sodium thiosulfate aqueous solution, a 10% sodium hydroxide aqueous solution, and water. The resulting reaction mixture having been washed was subjected to fractional distillation under reduced pressure to obtain 760 g of 1-bromo-3-chloro-4-ethoxy-2-fluorobenzene (C2). The resulting compound (C2) was white solid and had a melting point of 65.4 to 66.1° C. and a boiling point of 125 to 127° C./8 mmHg.

出典