反応 #2186175

反応方程式

benzoyl chloride

sorbitol

→

Sorbitol Hexabenzoate

収率 74.0%

溶媒

triethylamine

反応条件

後処理

1. 1
   workup.STIRRINGthe resulting mixture was stirred for an additional 30 minutes
2. 2
   その他After completion of the reaction
3. 3
   その他was lowered to room temperature
4. 4
   その他the resulting precipitates
5. 5
   ろ過were collected by filtration
6. 6
   洗浄Thereafter, washing
7. 7
   workup.ADDITIONby adding ethyl acetate-pure water
8. 8
   その他Subsequently, the organic phase was collected
9. 9
   workup.DISTILLATIONethyl acetate was distilled out under vacuum, whereby 100 parts by weight (at a yield of 74 percent) of white crystals
10. 10
    その他were obtained

実験手順

While stirring, 71 parts by weight of benzoyl chloride were dripped over 30 minutes into a mixed solution of 30 parts by weight of sorbitol and 101 parts by weight of triethylamine maintained at 100° C., and the resulting mixture was stirred for an additional 30 minutes. After completion of the reaction, the temperature was lowered to room temperature, and the resulting precipitates were collected by filtration. Thereafter, washing was performed by adding ethyl acetate-pure water. Subsequently, the organic phase was collected and ethyl acetate was distilled out under vacuum, whereby 100 parts by weight (at a yield of 74 percent) of white crystals were obtained. The molecular weight of the resulting compound was 809.

出典