反応 #2186167

反応方程式

acetone

sulfuric acid

L-ascorbic acid

→

5,6-O-isopropylidene-L-ascorbic acid

収率 115.4%

反応条件

後処理

1. 1
   その他The mixture was then reacted at the temperature of the previous step for 17 hours
2. 2
   ろ過filtered
3. 3
   洗浄washed with cold acetone

実験手順

With nitrogen substitution, 557.8 grams (9.6 moles) of acetone was cooled to −5 degrees C., 54.3 grams (0.2 moles) of 28% fuming sulfuric acid was dripped, and 176.1 grams (1.0 mole) of L-ascorbic acid was added. The mixture was then reacted at the temperature of the previous step for 17 hours, filtered and washed with cold acetone to obtain 249.5 grams of 5,6-O-isopropylidene-L-ascorbic acid (86.7% in purity) in the form of a wet cake.

出典