反応 #218050

反応方程式

6-(4-formyl-2-methoxyphenoxy)nicotinamide

hexylamine

→

title compound

収率 73.0%

6-(4-Hexylaminomethyl-2-methoxyphenoxy)nicotinamide

収率 73.0%

反応条件

実験手順

Using a method similar to Example 405, a reaction of 6-(4-formyl-2-methoxyphenoxy)nicotinamide (Example 414, Part B) (0.050 g, 0.184 mmol) and hexylamine (0.0186 g, 0.184 mmol) gives the title compound (0.0479 g, 73.0%): TOF MS ES+ 358.2 (M+H)+. HRMS calcd for C20H28N3O3 358.2131 (M+H)+, found 358.2124, time 0.41 min HPLC [YMC-Pack Pro C-18 (150×4.6 mm, S-5 microm), 0.1% TFA/acetonitrile in 0.1% TFA/water at 1.0 mL/min, 20-99% over 23 min], tR=7.4 min, 100% purity.

出典