反応 #217564

反応方程式

2-amino-N-(2-isopropyl-4-methoxymethyloctahydrocyclopenta[c]pyrrol-5-yl)acetamide

4-chloro-6-trifluoromethylquinazoline

triethylamine

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title product

N-(2-isopropyl-4-methoxymethyloctahydrocyclopenta[c]pyrrol-5-yl)-2-(6-trifluoromethylquinazolin-4-ylamino)acetamide

溶媒

ethanol

反応条件

後処理

1. 1
   温度is heated
2. 2
   温度at reflux until the reaction
3. 3
   濃縮The solution is concentrated under vacuum
4. 4
   その他yielding a residue
5. 5
   その他The residue is purified by reverse phase HPLC and lyophilization

実験手順

A mixture of 2-amino-N-(2-isopropyl-4-methoxymethyloctahydrocyclopenta[c]pyrrol-5-yl)acetamide, 4-chloro-6-trifluoromethylquinazoline (see Armarego et al., J. Chem. Soc. B, 1967, 449) and triethylamine in ethanol is heated at reflux until the reaction is complete. The solution is concentrated under vacuum yielding a residue. The residue is purified by reverse phase HPLC and lyophilization providing the title product.

出典