反応 #2175422

反応方程式

EDMA

1,4-butanediol

AIBN

methacrylate

→

11-acrylamidoundecanoic acid

溶媒

water

1-propanol

反応条件

後処理

1. 1
   その他For the preparation of stationary phases
2. 2
   その他purged with nitrogen for 10 min
3. 3
   その他sealed with rubber septum
4. 4
   その他to polymerize for 20 hours at 60° C
5. 5
   その他The reaction scheme for the polymerization
6. 6
   その他After the polymerization of the mixture
7. 7
   洗浄the monolithic column was washed with methanol for 12 hours
8. 8
   その他to remove unreacted monomers and porogens

実験手順

For the preparation of stationary phases, the inner walls of capillaries were vinylized with 3-(trimethoxylsilyppropyl methacrylate. Subsequently, AAUA, EDMA, 1-propanol, 1,4-butanediol, water, and AIBN were mixed ultrasonically into a homogenous solution and purged with nitrogen for 10 min. A 45 cm long silanized capillary was tilled with the polymerization mixture up to a length of 35 cm, sealed with rubber septum, and then placed in a gas chromatography (GC) oven to polymerize for 20 hours at 60° C. The reaction scheme for the polymerization is shown in Scheme 1. Each column of the experimental design was made in duplicate. After the polymerization of the mixture, the monolithic column was washed with methanol for 12 hours using a HPLC pump to remove unreacted monomers and porogens. An on-column detection window was made next to the polymer bed using a thermal wire stripper. Finally, the column was cut to 45 cm with an effective length of 30 cm.

出典