反応 #2175419

反応方程式

1-bromo-2,4-difluorobenzene

N,N′-dimethyl-ethylenediamine

NaO-t-Bu

→

N-(2,4-difluoro-phenyl)-N,N′-dimethylethylenediamine

溶媒

toluene

反応条件

後処理

1. 1
   温度Heat at 110° for 18 h
2. 2
   温度to cool
3. 3
   抽出extract with 1N HCl
4. 4
   抽出extract with CH2Cl2
5. 5
   その他Dry
6. 6
   濃縮concentrate
7. 7
   その他purify by PLC

実験手順

Combine 1-bromo-2,4-difluorobenzene (1.00 g, 5.18 mmol), N,N′-dimethyl-ethylenediamine (2.74 g, 31.1 mmol), NaO-t-Bu (0.70 g, 7.2 mmol), Pd(dba)2 (0.060 g, 0.10 mmol) and (±)-BINAP (0.19 g, 0.31 mmol) in toluene (10 ml). Heat at 110° for 18 h, allow to cool, and extract with 1N HCl. Basify the aqueous solution with NaOH and extract with CH2Cl2. Dry, concentrate, and purify by PLC to give N-(2,4-difluoro-phenyl)-N,N′-dimethylethylenediamine.

出典