反応 #217155

反応方程式

1-dimethylcarbamoyl-3-t-butyl-5-carboethoxymethylthio-1H-1,2,4-triazole

compound

1-dimethylcarbamoyl-3-t-butyl-5-carboethoxymethylthio-1,2,4-1H-triazole

HCl

→

1-dimethylcarbamoyl-3t-butyl-5-carboxymethylthio-1H-1,2,4-triazole

溶媒

THF

反応条件

後処理

1. 1
   その他was partitioned between ether and water
2. 2
   抽出the ether layer was extracted with dilute NaOH
3. 3
   抽出extracted with fresh ether
4. 4
   乾燥The resulting ether layer was dried over magnesium sulfate
5. 5
   ろ過filtered
6. 6
   その他evaporated under vacuum

実験手順

To 1.2 g of 1-dimethylcarbamoyl-3-t-butyl-5-carboethoxymethylthio-1H-1,2,4-triazole (the compound of Example 2) in 20 ml of THF was added 4 ml of 12M HCl. After stirring for 48 h at 200° C. the reaction mixture was partitioned between ether and water, the ether layer was extracted with dilute NaOH and the resulting aqueous layer was acidified and extracted with fresh ether. The resulting ether layer was dried over magnesium sulfate, filtered and evaporated under vacuum to yield 1-dimethylcarbamoyl-3t-butyl-5-carboxymethylthio-1H-1,2,4-triazole as an oil.

出典