反応 #2171037

反応方程式

bromine

triphenylphosphine

4-(trans-4-ethyl-cyclohexyl)cyclohexanol

→

4′-bromo-4-ethylbicyclohexane

溶媒

acetonitrile

反応条件

後処理

1. 1
   workup.STIRRINGthe mixture is stirred at RT for 24 hours

実験手順

102 ml of bromine are added dropwise over the course of 2 hours at 5-15° C. to 536 g of triphenylphosphine in 2000 ml of acetonitrile, the mixture is subsequently stirred at 5° C. for 1 hour, 422 g of 4-(trans-4-ethyl-cyclohexyl)cyclohexanol are added, and the mixture is stirred at RT for 24 hours. Conventional work-up gives 4′-bromo-4-ethylbicyclohexane, GC 94.7%.

出典