反応 #216990

反応方程式

Phenol

3,4-dihydro-2H-pyran

→

title compound

収率 100.0%

Tetrahydro-2-phenoxy-2H-pyran

収率 100.0%

溶媒

Ethyl ether

反応条件

後処理

1. 1
   workup.ADDITIONto dilute
2. 2
   その他the reaction
3. 3
   洗浄The organic layer was washed with water (2×100 mL), saturated sodium bicarbonate (2×100 mL), brine (2×100 mL)
4. 4
   乾燥dried over MgSO4
5. 5
   その他Evaporation

実験手順

Phenol (10 g, 106 mmol) was dissolved in 3,4-dihydro-2H-pyran (29 mL, 318 mmol) and one drop concentrated HCl was added at RT. The reaction was stirred at RT overnight. Ethyl ether (500 mL) was added to dilute the reaction. The organic layer was washed with water (2×100 mL), saturated sodium bicarbonate (2×100 mL), brine (2×100 mL) and dried over MgSO4. Evaporation gave title compound (17 g, 100%) as a colorless oil.

出典