反応 #216906

反応方程式

Pyridine-4-carbaldehyde

L-cysteine

charcoal

→

2-(4-pyridyl)-thiazolidine-4-carboxylic acid

収率 57.1%

溶媒

ethanol

反応条件

後処理

1. 1
   温度was warm
2. 2
   ろ過The mixture was filtered
3. 3
   温度After cooling
4. 4
   ろ過the resultant crystalline precipitate was collected by filtration
5. 5
   洗浄washed with ethanol

実験手順

Pyridine-4-carbaldehyde (1.07 g) and 1.21 g of L-cysteine were heated in 60% ethanol at a refluxing temperature for 4 hours. Activated charcoal (100 mg) was added to the reaction mixture while it was warm. The mixture was filtered. After cooling, the resultant crystalline precipitate was collected by filtration and washed with ethanol to give 1.2 g of 2-(4-pyridyl)-thiazolidine-4-carboxylic acid. Melting point 171°-173° C.

出典