反応 #216796

反応方程式

6-bromo-4,4-dibutylthiochroman

Compound 33

6-bromo-4,4-dibutylthiochroman

triethylamine

(trimethylsilyl)acetylene

→

(4,4-Dibutylthiochroman-6-yl)(trimethylsilyl)acetylene

反応条件

後処理

1. 1
   その他was degassed with argon for 15 minutes at -78° C
2. 2
   その他The solution was degassed with argon for an additional 5 minutes
3. 3
   その他The tube was sealed
4. 4
   温度the mixture was heated to 55° C. for 22 hours

実験手順

A mixture of 1.68 g (5.38 mmol) of 6-bromo-4,4-dibutylthiochroman (Compound 33), 0.28 g (1.5 mmol) of copper (I) iodide and 2.5 g (25 mmol) of triethylamine was degassed with argon for 15 minutes at -78° C. To the suspension was added 1.18 g (71 mmol) of (trimethylsilyl)acetylene and 0.24 g (0.35 mmol) of bis(triphenylphosphine)palladium (II) chloride. The solution was degassed with argon for an additional 5 minutes and the resulting mixture was allowed to warm to 0° C. The tube was sealed and the mixture was heated to 55° C. for 22 hours.

出典