反応 #216790

反応方程式

(trimethylsilyl)acetylene

6-bromo-4,4-diethylthiochroman

Compound 25

6-bromo-4,4-diethylthiochroman

triethylamine

→

(4,4-Diethylthiochroman-6-yl)(trimethylsilyl)acetylene

反応条件

後処理

1. 1
   その他was degassed with argon for 15 minutes at -78° C
2. 2
   その他The solution was degassed with argon for an additional 5 minutes
3. 3
   その他The tube was sealed
4. 4
   温度the mixture heated to 55° C. for 15 hours

実験手順

A mixture of 1.96 g (6.90 mmol) of 6-bromo-4,4-diethylthiochroman (Compound 25), 0.11 g (0.59 mmol) of copper (I) iodide and 4.36 g (4.31 mmol) of triethylamine was degassed with argon for 15 minutes at -78° C. To the suspension was added 6.95 g (71 mmol) of (trimethylsilyl)acetylene then 0.41 g (58 mmol) of bis(triphenylphosphine)palladium (II) chloride. The solution was degassed with argon for an additional 5 minutes and the resulting mixture was allowed to warm to 0° C. The tube was sealed and the mixture heated to 55° C. for 15 hours.

出典