反応 #2167482

反応方程式

(R)-tert-butyl 2-(azidomethyl)azetidine-1-carboxylate

hydrogen

→

(R)-tert-butyl 2-(aminomethyl)azetidine-1-carboxylate

収率 100.0%

溶媒

MeOH

反応条件

後処理

1. 1
   ろ過The catalyst was filtered off
2. 2
   濃縮the filtrate was concentrated

実験手順

A mixture of (R)-tert-butyl 2-(azidomethyl)azetidine-1-carboxylate (17 g, 80 mmol), 10% Pd/C (2 g) and MeOH (150 mL) was stirred under 45 psi hydrogen for 1 hour. The catalyst was filtered off and the filtrate was concentrated to give (R)-tert-butyl 2-(aminomethyl)azetidine-1-carboxylate (14.9 g, yield 100%). LRMS (M+H+) m/z 187.3.

出典