反応 #216744

反応方程式

1-cyano-2-methoxybenzene

tributyltin azide

→

5-(2-methoxyphenyl)-2H-tetrazole

収率 98.1%

溶媒

diethyl ether

xylene

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度under reflux for 5 hours
3. 3
   温度The reaction mixture then was cooled
4. 4
   その他Anhydrous hydrochloric acid was bubbled into the mixture
5. 5
   その他a white precipitate formed
6. 6
   ろ過The precipitate was collected by suction filtration
7. 7
   洗浄washed repeatedly with diethyl ether
8. 8
   その他Drying

実験手順

A mixture of 1-cyano-2-methoxybenzene (1.02 g, 7.7 mmol) and tributyltin azide (3.4 g, 10.0 mmol) in 3.0 mL of xylene was heated under reflux for 5 hours. The reaction mixture then was cooled and diluted with diethyl ether. Anhydrous hydrochloric acid was bubbled into the mixture and a white precipitate formed. The precipitate was collected by suction filtration and washed repeatedly with diethyl ether. Drying gave 5-(2-methoxyphenyl)-2H-tetrazole (1.33 g, 7.55 mmol).

出典