反応 #2166

反応方程式

6-(4-chlorophenyl)-4,5-dihydropyridazinone

acetic acid

bromine

→

6-(4-chlorophenyl)pyridazinone

収率 93.1%

溶媒

water

反応条件

後処理

1. 1
   温度the mixture was heated at 60°-70° C. for 3 h
2. 2
   温度The resulting mixture was cooled
3. 3
   ろ過The resulting white solid was filtered
4. 4
   その他dried

実験手順

To a solution of 6-(4-chlorophenyl)-4,5-dihydropyridazinone (11.75 g) and glacial acetic acid (100 ml) was added dropwise 3 ml of bromine and the mixture was heated at 60°-70° C. for 3 h. The resulting mixture was cooled and slowly poured into 400 ml of cold water. The resulting white solid was filtered and dried to yield 10.83 g (89%) of 6-(4-chlorophenyl)pyridazinone.

出典