反応 #216175

反応方程式

Indole-3-carboxylic acid

diazomethane

→

compound

1H-Indole-3-carboxylic acid, methyl ester

溶媒

ether

ethyl acetate

methanol

ether

反応条件

後処理

1. 1
   その他The solvent was removed in vacuo
2. 2
   洗浄eluting with dichloromethane

実験手順

Indole-3-carboxylic acid (757 mg, 4.7 mmol, 1.0 eq.) was partially dissolved in a mixture of ether, ethyl acetate and methanol. While stirring, a solution of diazomethane in ether was added until a yellow color persisted. The solvent was removed in vacuo and the remaining white solid was passed through a silica gel column, eluting with dichloromethane to give the title A compound (819 mg), m.p. 147°-149° C.

出典