反応 #2161260
ord-7b820546f2d545e2821f6791b2f5d07c
反応方程式
ethyl 1-ethyl-4-nitro-1H-imidazole-2-carboxylate
N-(pyridin-2-yl)piperazine
→
crude mixture
1-[(1-Ethyl-4-nitro-1H-imidazol-2-yl)carbonyl]-4-(pyridin-2-yl)piperazine
反応条件
温度
100°CELSIUS
詳細条件
See reaction.notes.procedure_details.
実験手順
A mixture of 1.23 g (5.06 mmol) of ethyl 1-ethyl-4-nitro-1H-imidazole-2-carboxylate (prepared in analogy to Example 10A) and 2.48 g (15.2 mmol) of N-(pyridin-2-yl)piperazine is stirred at 100° C. overnight. For the work-up, the crude mixture obtained is purified by preparative HPLC. 0.724 g (43% of theory) of product are obtained.