反応 #2161259

反応方程式

2-bromo-5-fluoropyridine

piperazine

→

1-(5-Fluoropyridin-2-yl)piperazine

反応条件

後処理

1. 1
   温度After cooling
2. 2
   workup.DISTILLATIONexcess piperazine is distilled off in vacuo (Kugelrohr, 1.5 mbar, 120° C.)
3. 3
   その他The residue is purified by flash chromatography (dichloromethane/ethanol/conc. ammonia solution, 30:1:0.1)

実験手順

With stirring, 500 mg (2.84 mmol) of 2-bromo-5-fluoropyridine and 1.22 g (14.2 mmol) of piperazine are heated at 150° C. for 24 h. After cooling, excess piperazine is distilled off in vacuo (Kugelrohr, 1.5 mbar, 120° C.). The residue is purified by flash chromatography (dichloromethane/ethanol/conc. ammonia solution, 30:1:0.1).

出典