反応 #2161258

反応方程式

1-(tert-butyloxycarbonyl)-4-(5-methylpyridin-2-yl)piperazine

hydrogen chloride

→

1-(5-Methylpyridin-2-yl)piperazine

溶媒

dioxane

dioxane

反応条件

後処理

1. 1
   濃縮The mixture is then concentrated
2. 2
   抽出extracted several times with dichloromethane
3. 3
   乾燥The combined organic phases are dried over sodium sulfate
4. 4
   濃縮concentrated
5. 5
   その他dried in vacuo

実験手順

3.47 g (12.5 mmol) of 1-(tert-butyloxycarbonyl)-4-(5-methylpyridin-2-yl)piperazine are dissolved in 10 ml of dioxane, and 31 ml (125 mmol) of hydrogen chloride in dioxane (4 molar) are added. The mixture is stirred at RT for 2 h. The mixture is then concentrated and the residue is rendered alkaline using a 1M aqueous sodium hydroxide solution and extracted several times with dichloromethane. The combined organic phases are dried over sodium sulfate, concentrated and dried in vacuo.

出典