反応 #2161251

反応方程式

ethyl 1-(cyclopropylmethyl)-4-nitro-1H-imidazole-2-carboxylate

hydrogen

→

Ethyl 4-amino-1-(cyclopropylmethyl)-1H-imidazole-2-carboxylate

溶媒

THF

反応条件

後処理

1. 1
   ろ過The catalyst is filtered off
2. 2
   濃縮the filtrate is concentrated in vacuo
3. 3
   その他The concentration residue is directly used further for the next reaction

実験手順

3.89 g (16.26 mmol) of ethyl 1-(cyclopropylmethyl)-4-nitro-1H-imidazole-2-carboxylate are dissolved in 50 ml of THF, and a spatula tip of Raney nickel is added. In a hydrogenation apparatus, the reaction mixture is hydrogenated with hydrogen at room temperature. The catalyst is filtered off and the filtrate is concentrated in vacuo. The concentration residue is directly used further for the next reaction.

出典