反応 #2161249

反応方程式

ethyl imidazole-2-carboxylate

nitric acid

→

Ethyl 4-nitro-1H-imidazole-2-carboxylate

溶媒

反応条件

後処理

1. 1
   温度after cooling
2. 2
   ろ過The precipitated crystals are collected by suction filtration
3. 3
   洗浄washed with 1500 ml of ice-water

実験手順

While cooling on ice, 16.08 g (114.7 mmol) of ethyl imidazole-2-carboxylate are dissolved in 71.7 ml of concentrated sulpfuric acid. 71.7 ml of 100% fuming nitric acid are then added dropwise. The reaction solution is stirred at 50 to 60° C. for 3 h and, after cooling, poured onto 800 ml of an ice/water mixture. The precipitated crystals are collected by suction filtration and washed with 1500 ml of ice-water.

出典