反応 #2161248

反応方程式

ammonium formate

ethyl 1-benzyl-1H-imidazole-2-carboxylate

ammonium formate

→

Ethyl imidazole-2-carboxylate

溶媒

ethanol

反応条件

後処理

1. 1
   温度The reaction mixture is heated
2. 2
   温度under reflux for about 6 h
3. 3
   温度After cooling
4. 4
   ろ過the catalyst is filtered off
5. 5
   濃縮the filtrate is concentrated in vacuo
6. 6
   その他The product that crystallizes out during this operation
7. 7
   その他is triturated with 80 ml of ice-water
8. 8
   ろ過collected by suction filtration

実験手順

34.7 g (150.9 mmol) of ethyl 1-benzyl-1H-imidazole-2-carboxylate are dissolved in 1005 ml of ethanol, and 34 g of ammonium formate are added. The reaction mixture is heated under reflux for about 6 h. A total of 8 g of 10% palladium-on-carbon and 18 g of ammonium formate are thereby added in small portions. After cooling, the catalyst is filtered off and the filtrate is concentrated in vacuo. The product that crystallizes out during this operation is triturated with 80 ml of ice-water and collected by suction filtration.

出典