反応 #2161230

反応方程式

5-aminoindane

acetic anhydride

→

5-(N-acetylamino)indane

収率 84.6%

溶媒

—

ice water

acetic acid

反応条件

後処理

1. 1
   その他After completion of the reaction
2. 2
   その他the reaction liquid
3. 3
   workup.STIRRINGwhile stirring
4. 4
   その他Crystals precipitated
5. 5
   ろ過were filtered off
6. 6
   洗浄washed with 1,000 ml of water The crystals
7. 7
   その他obtained
8. 8
   その他were dried

実験手順

33.3 g (0.25 mol) of 5-aminoindane (a product of Tokyo Chemical Industry Co., Ltd.) was dissolved in 250 ml of glacial acetic acid, the resulting solution was heated to 50° C., and 51.0 g (0.5 mol) of acetic anhydride was added dropwise thereto. After completion of the dropwise additions the resulting solution was stirred for 4 hours. After completion of the reaction, the reaction liquid was poured in 1,500 ml of ice water while stirring. Crystals precipitated were filtered off and washed with 1,000 ml of water The crystals obtained were dried to obtain 37.06 g of 5-(N-acetylamino)indane (yield: 84.6%, melting point: 100.5 to 103-85° C.)

出典