反応 #2161222

反応方程式

sodium azide

undecenyl bromide

water

→

undecenyl azide

収率 60.0%

溶媒

dimethylformamide

反応条件

後処理

1. 1
   workup.WAITThe mixture was left
2. 2
   温度to cool to ambient temperature
3. 3
   抽出An extraction with ethanol (3×100 ml)
4. 4
   洗浄the organic phase was then washed with water (3×100 ml)
5. 5
   乾燥dried over sodium sulfate (Na2SO4)
6. 6
   その他Finally, the solvent was evaporated off

実験手順

To do this, sodium azide (2.781 g, 43 mmol) was dissolved in 170 ml of dimethylformamide (DMF). 5 ml of undecenyl bromide (36 mmol) were added, with stirring, to the reaction medium, which was subsequently heated at 80° C. for 24 hours. The mixture was left to cool to ambient temperature, and then 100 ml of water were added portionwise. An extraction with ethanol (3×100 ml) was subsequently carried out, and the organic phase was then washed with water (3×100 ml) and dried over sodium sulfate (Na2SO4). Finally, the solvent was evaporated off and 2.58 g of undecenyl azide (20.3 mmol; yield 60%) were isolated in the form of a pale yellow-colored transparent oil.

出典