反応 #215867

反応方程式

1-(2,4,6-trimethylphenyl)-1-ethanone

bromine

→

2-bromo-1-(2,4,6-trimethylphenyl)-1-ethanone

溶媒

acetic acid

反応条件

後処理

1. 1
   温度while maintaining the reaction medium at a temperature below 10° C
2. 2
   workup.ADDITIONWhen the addition
3. 3
   その他to return to room temperature
4. 4
   その他leave at this temperature for 2 hours
5. 5
   抽出extract the aqueous phase with ethyl ether
6. 6
   洗浄Wash the organic extracts with saturated aqueous sodium bicarbonate solution
7. 7
   乾燥with salt water, and dry over anhydrous magnesium sulphate

実験手順

Dissolve 0.3 mol of 1-(2,4,6-trimethylphenyl)-1-ethanone in 200 ml of glacial acetic acid, and add 31.8 g of bromine dropwise while maintaining the reaction medium at a temperature below 10° C. When the addition is complete, allow the reaction medium to return to room temperature and leave at this temperature for 2 hours. Then pour the reaction medium into 500 ml of ice-cold water and extract the aqueous phase with ethyl ether. Wash the organic extracts with saturated aqueous sodium bicarbonate solution and then with salt water, and dry over anhydrous magnesium sulphate.

出典