反応 #215704

反応方程式

sodium fluoride

ethyl 2-(2-bromo-3,4,5,6-tetrafluoro-benzoyl)-3-cyclopropylamino-acrylate

water

→

Ethyl 5-bromo-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

溶媒

dimethylformamide

反応条件

後処理

1. 1
   温度After cooling
2. 2
   その他the precipitate (red) which has separated out
3. 3
   ろ過is filtered off with suction
4. 4
   洗浄washed with a large quantity of water
5. 5
   その他dried at 80° C. in a circulating air cabinet

実験手順

28 g (68 mmol) of ethyl 2-(2-bromo-3,4,5,6-tetrafluoro-benzoyl)-3-cyclopropylamino-acrylate are heated under reflux in 88 ml of dimethylformamide with 6.9 g (164 mmol) of sodium fluoride for 6 hours. After cooling, the mixture is poured into water and the precipitate (red) which has separated out is filtered off with suction, washed with a large quantity of water and dried at 80° C. in a circulating air cabinet.

出典