反応 #215700

反応方程式

2-bromo-3,4,5,6-tetrafluorobenzoic acid

thionyl chloride

thionyl chloride

→

2-Bromo-3,4,5,6-tetrafluoro-benzoyl chloride

反応条件

後処理

1. 1
   温度the mixture is heated
2. 2
   温度under reflux for 11 hours until the evolution of gas stops
3. 3
   workup.DISTILLATIONthe residue is distilled

実験手順

365 g (1.33 mol) of 2-bromo-3,4,5,6-tetrafluorobenzoic acid [Tetrahedron 2.3, 4719 (1967)] are introduced into 2 l of thionyl chloride and the mixture is heated under reflux for 11 hours until the evolution of gas stops. Excess thionyl chloride is stripped off in vacuo and the residue is distilled.

出典