反応 #215519

反応方程式

4-(2-cyclohexylethylamino)phenylacetic acid

lactic acid

toluenesulfonic acid

→

1-carboxyethyl 4-(2-cyclohexylethylamino)-phenylacetate

溶媒

toluene

反応条件

後処理

1. 1
   workup.ADDITIONA flask containing 10.0 g
2. 2
   workup.ADDITIONcharged
3. 3
   温度The solution is refluxed for 24 hours during which time the Soxhlet extractor
4. 4
   workup.ADDITIONis charged twice more with fresh sieves
5. 5
   ろ過The hot solution is filtered
6. 6
   workup.WAITleft
7. 7
   温度to cool, whereupon 1-carboxyethyl 4-(2-cyclohexylethylamino)phenylacetate

実験手順

A flask containing 10.0 g. 4-(2-cyclohexylethylamino)phenylacetic acid, 3.3 g. lactic acid, 500 mg. toluenesulfonic acid and 500 ml. toluene equipped with a Soxhlet extractor charged with activated 4 A Linde molecular sieves. The solution is refluxed for 24 hours during which time the Soxhlet extractor is charged twice more with fresh sieves. The hot solution is filtered and left to cool, whereupon 1-carboxyethyl 4-(2-cyclohexylethylamino)phenylacetate separates as off-white crystals.

出典