反応 #2155129

反応方程式

4-[1-Dimethylamino-eth-(Z)-ylidene]-2-methyl-4H-oxazol-5-one

ethanol

sodium hydride

→

(Z)-2-Acetylamino-3-dimethylamino-but-2-enoic acid ethyl ester

反応条件

後処理

1. 1
   温度The dark solution was refluxed for 1 h
2. 2
   その他The solvent was evaporated
3. 3
   その他the crude product [MS: m/e=215.5 (M+H+)] was used without any further purification for the next step

実験手順

4-[1-Dimethylamino-eth-(Z)-ylidene]-2-methyl-4H-oxazol-5-one (7.4 g, 44.0 mmol) was dissolved in ethanol (50 ml), and sodium hydride (0.10 g, 4.4 mmol) was added at room temperature. The dark solution was refluxed for 1 h. The solvent was evaporated, and the crude product [MS: m/e=215.5 (M+H+)] was used without any further purification for the next step.

出典