反応 #215410

反応方程式

m-phenoxybenzyl cyanide

butyl chloride

sodium hydroxide

→

pure product

収率 54.8%

2-(3-Phenoxyphenyl)hexanenitrile

収率 54.8%

溶媒

water

反応条件

後処理

1. 1
   温度The reaction mixture is heated at 90° for three hours
2. 2
   抽出extracted with hexane
3. 3
   洗浄The combined hexane extracts are washed with water
4. 4
   乾燥dried over MgSO4
5. 5
   その他Solvent is evaporated
6. 6
   その他to give 39 g of crude product
7. 7
   workup.DISTILLATIONVacuum distillation (149°-155°/0.2 mm)

実験手順

Into a three-necked 500 ml round-bottom flask are charged 35 g (0.17 mole) of m-phenoxybenzyl cyanide, 16.3 g (0.17 mole) of butyl chloride 4 g of tetraethylammonium bromide. To this mixture is added 27 g (0.34 mole) of 50% sodium hydroxide solution dropwise with stirring. The reaction mixture is heated at 90° for three hours. It is then poured into water and extracted with hexane. The combined hexane extracts are washed with water and dried over MgSO4. Solvent is evaporated to give 39 g of crude product. Vacuum distillation (149°-155°/0.2 mm) provides 24.7 g of pure product.

出典