反応 #215141

反応方程式

3-sulfamoyl-4-chlorobenzoyl chloride

1-phenyl-1-n-propylhydrazine

sodium bicarbonate

isopropanol

→

1-n-Propyl-1-phenyl-2-(3-sulfamoyl-4 chlorobenzoyl) hydrazine

溶媒

water

反応条件

後処理

1. 1
   温度was chilled to 0°-5° C.
2. 2
   その他was collected
3. 3
   その他recrystallized from acetone/water, mp. 102° C. (d)

実験手順

A vigorously stirred mixture of 14.0 g (0.1 mol) 1-phenyl-1-n-propylhydrazine, 8.4 g (0.1 mol) sodium bicarbonate, and 100 ml isopropanol was chilled to 0°-5° C., 23 g (0.09 mol) 3-sulfamoyl-4-chlorobenzoyl chloride was added in one portion, and the reaction mixture was allowed to stir for several hours, gradually warming to room temperature. Dilution with water and refrigeration overnight yielded solid material which was collected and recrystallized from acetone/water, mp. 102° C. (d).

出典