反応 #215107

反応方程式

2,4-diamino-5-(3-benzyloxy-4-methoxybenzyl)pyrimidine

hydrochloric acid

hydrogen

→

2,4-Diamino-5-(3'-hydroxy-4'-methoxybenzyl)pyrimidine hydrochloride

溶媒

methanol

反応条件

後処理

1. 1
   その他(3.5 hr.)
2. 2
   ろ過is filtered
3. 3
   濃縮the filtrate concentrated in vacuo to 250 ml

実験手順

A solution of 55 g (0.15 mole) of 2,4-diamino-5-(3-benzyloxy-4-methoxybenzyl)pyrimidine from the preceding step in 2500 ml of methanol and 20 ml of concentrated hydrochloric acid is hydrogenated at about 2.5 to 3.0 atm. in the presence of 4 g of 10% Palladium-on-charcoal catalyst. After the uptake of hydrogen has stopped (3.5 hr.) the catalyst is filtered and the filtrate concentrated in vacuo to 250 ml. The crystalline product weighs 41.5 g (90%), m.p. 230°-32°.

出典