反応 #215030

反応方程式

ammonia

7-chloro-5-(2-fluorophenyl)-2,3-dihydro-N-hydroxy-α-(4-morpholinyl)-1H-1,4-benzodiazepine-2-methanimine 4-oxide

acetaldehyde

→

8-Chloro-6-(2-fluorophenyl)-1-methyl-3-morpholino-4H-imidazo[1,5-a][1,4]benzodiazepine 5-oxide

溶媒

acetic acid

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度to reflux for 5 minutes
3. 3
   その他The cooled reaction mixture
4. 4
   workup.ADDITIONwas poured on ice
5. 5
   抽出extracted with methylene chloride
6. 6
   その他The extracts were dried
7. 7
   その他evaporated
8. 8
   その他the residue was crystallized from ether/2-propanol
9. 9
   その他to yield yellow crystals

実験手順

A mixture of 4.2 g (0.01 mole) of 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-N-hydroxy-α-(4-morpholinyl)-1H-1,4-benzodiazepine-2-methanimine 4-oxide, 50 ml of glacial acetic acid and 4 ml of acetaldehyde was heated to reflux for 5 minutes. The cooled reaction mixture was poured on ice, made alkaline with ammonia and extracted with methylene chloride. The extracts were dried and evaporated and the residue was crystallized from ether/2-propanol to yield yellow crystals.

出典