反応 #214913

反応方程式

diglycolic anhydride

methanesulfonate

4-aminobutanol

→

[2-(4-hydroxybutyl]amino-2-oxoethoxy]acetic acid

反応条件

実験手順

methanesulfonate by (a) reacting diglycolic anhydride and 4-aminobutanol to produce [2-(4-hydroxybutyl]amino-2-oxoethoxy]acetic acid, (b) heating to cyclize the latter to obtain 4-(4-hydroxybutyl)-3,5-dioxomorpholine, (c) esterifying the latter with methanesulfonyl chloride to produce 4-(3,5-dioxomorpholino)butyl methanesulfonate and (d) reacting the mesylate with 3[bis(4-butoxy-o-tolyl)methyl]piperidine.

出典