反応 #214876

反応方程式

5-fluorouracil

2,3-dihydrofuran

→

1-(2-tetrahydrofuryl)-5-fluorouracil

収率 69.0%

溶媒

pyridine

pyridine

pyridine

反応条件

後処理

1. 1
   温度cooled
2. 2
   その他was removed from the reaction liquid by distillation and 500 ml of chloroform and 5 g of silica gel
3. 3
   workup.ADDITIONwere added to the residue
4. 4
   ろ過filtered
5. 5
   濃縮the filtrate was concentrated

実験手順

In 40 ml of pyridine were dissolved 5.2 g of 5-fluorouracil. The solution was ice cooled and 0.8 g of titanium tetrachloride was added thereto. Then, 6 ml of 2,3-dihydrofuran in 20 ml of pyridine were added to the mixture in 1.5 hours while stirring it at 80° C. The reaction was continued for 4 hours. After completion of the reaction, pyridine was removed from the reaction liquid by distillation and 500 ml of chloroform and 5 g of silica gel were added to the residue. The mixture was decolored and filtered and the filtrate was concentrated to obtain 5.5 g of 1-(2-tetrahydrofuryl)-5-fluorouracil in a yield of 69%.

出典