反応 #214874

反応方程式

5-fluorouracil

triethylamine hydrochloride

2,3-dihydrofuran

→

1-(2-tetrahydrofuryl)-5-fluorouracil

溶媒

dimethylformamide

dimethylformamide

反応条件

後処理

1. 1
   その他the mixture was reacted in an autoclave for 16 hours at 150° C
2. 2
   その他was removed from the reaction liquid by distillation
3. 3
   workup.ADDITIONthe residue was treated in the same manner

実験手順

In 15 ml of dimethylformamide were dissolved 1.3 g of 5-fluorouracil and 0.41 g of triethylamine hydrochloride. To this solution were added 3 ml of 2,3-dihydrofuran and the mixture was reacted in an autoclave for 16 hours at 150° C. After the reaction, dimethylformamide was removed from the reaction liquid by distillation and the residue was treated in the same manner as described in Example 7 to obtain 0.8 g of 1-(2-tetrahydrofuryl)-5-fluorouracil. From the chloroform insoluble matter 0.6 g of the starting 5-fluorouracil was recovered. The yield of the end product was 74% based on the consumed 5-fluorouracil.

出典