反応 #214871

反応方程式

5-fluorouracil

2,3-dihydrofuran

5-fluorouracil

→

1-(2-tetrahydrofuryl)-5-fluorouracil

収率 56.0%

溶媒

methyl ethyl ketone

反応条件

後処理

1. 1
   その他the mixture was reacted in an autoclave for 2 hours at 180° C
2. 2
   その他After completion of the reaction
3. 3
   その他the reaction liquid
4. 4
   workup.ADDITIONwas treated in the same manner
5. 5
   その他was recovered as a substance insoluble in chloroform

実験手順

Into 30 ml of methyl ethyl ketone were suspended 1.3 g of 5-fluorouracil. To this suspension were added 1.4 g of 2,3-dihydrofuran and the mixture was reacted in an autoclave for 2 hours at 180° C. After completion of the reaction, the reaction liquid was treated in the same manner as described in Example 1 whereby 0.38 g of the starting 5-fluorouracil was recovered as a substance insoluble in chloroform and 1.12 g of 1-(2-tetrahydrofuryl)-5-fluorouracil were obtained. The yield of the end product was 79% based on the consumed 5-fluorouracil.

出典