反応 #214870

反応方程式

5-fluorouracil

2,3-dihydrofuran

5-fluorouracil

→

1-(2-tetrahydrofuryl)-5-fluorouracil

収率 64.0%

溶媒

tetrahydrofuran

反応条件

後処理

1. 1
   その他the mixture was reacted in an autoclave for 5 hours at 170° C
2. 2
   その他After completion of the reaction
3. 3
   その他the reaction liquid
4. 4
   workup.ADDITIONwas treated in the same manner
5. 5
   その他was recovered as a substance insoluble in chloroform

実験手順

Into 30 ml of tetrahydrofuran were suspended 1.3 g of 5-fluorouracil. To this suspension were added 1.4 g of 2,3-dihydrofuran and the mixture was reacted in an autoclave for 5 hours at 170° C. After completion of the reaction, the reaction liquid was treated in the same manner as described in Example 1 whereby 0.30 g of the starting 5-fluorouracil was recovered as a substance insoluble in chloroform and 1.28 g of 1-(2-tetrahydrofuryl)-5-fluorouracil were obtained. The yield of the end product was 83.2% based on the consumed 5-fluorouracil.

出典