反応 #214770

反応方程式

1-methyl-β-oxo-α-ethoxycarbonyl-2-pyrrolpropionitrile

p-aminophenol

→

1-methyl-β-oxo-α-(p-hydroxyphenylcarbamoyl)-2-pyrrolpropionitrile

溶媒

xylene

反応条件

後処理

1. 1
   温度is refluxed for 2 hours
2. 2
   ろ過filtered hot
3. 3
   温度The filtrate is chilled
4. 4
   その他the crystals formed
5. 5
   その他collected
6. 6
   その他recrystallized from methanol

実験手順

The mixture of 5.7 g of 1-methyl-β-oxo-α-ethoxycarbonyl-2-pyrrolpropionitrile, 3,6 g of p-aminophenol and 300 ml of xylene is refluxed for 2 hours and filtered hot. The filtrate is chilled, the crystals formed collected and recrystallized from methanol, to yield the 1-methyl-β-oxo-α-(p-hydroxyphenylcarbamoyl)-2-pyrrolpropionitrile melting at 182°-184°.

出典