反応 #2147688

反応方程式

[(1-chloro-4-methoxy-isoquinoline-3-carbonyl)-amino]-acetic acid methyl ester

KOH

→

title compound

[(1-Chloro-4-methoxy-isoquinoline-3-carbonyl)-amino]-acetic acid

溶媒

EtOH

反応条件

後処理

1. 1
   その他Then the solvent was evaporated in vacuo
2. 2
   workup.DISSOLUTIONThe residue was dissolved in water (2 ml)
3. 3
   workup.ADDITIONthe pH of the solution was adjusted to 2-3 by the addition of aqueous 1N HCl
4. 4
   抽出The mixture was extracted with EtOAc (4×10 ml)
5. 5
   乾燥phases were dried over MgSO4
6. 6
   その他evaporated in vacuo

実験手順

A mixture of [(1-chloro-4-methoxy-isoquinoline-3-carbonyl)-amino]-acetic acid methyl ester (21 mg, 0.07 mmol), KOH (23 mg, 0.35 mmol) and EtOH (1 ml) was stirred at ambient temperature for 3 h. Then the solvent was evaporated in vacuo. The residue was dissolved in water (2 ml) and the pH of the solution was adjusted to 2-3 by the addition of aqueous 1N HCl. The mixture was extracted with EtOAc (4×10 ml). The combined org. phases were dried over MgSO4 and evaporated in vacuo to give the title compound as a slightly yellowish solid (18 mg); MS-(+)-ion: M+1=295.0.

出典