反応 #2146687

反応方程式

water

2-(4′-hydroxyphenyl)-6-methoxyimidazo[1,2-a]pyridine

potassium carbonate

1-bromo-3-fluoropropane

→

2-[4′-(3″-fluoropropoxy)phenyl]-6-methoxyimidazo[1,2-a]pyridine

収率 63.0%

溶媒

chloroform

反応条件

後処理

1. 1
   その他to remove moisture
2. 2
   workup.DISSOLUTIONwas dissolved in 10 L of N,N-dimethylformamide
3. 3
   その他After the completion of the reaction
4. 4
   抽出extracted three times with chloroform
5. 5
   洗浄The combined chloroform layer was washed once with water and once with a saturated sodium chloride solution
6. 6
   乾燥dried over anhydrous sodium sulfate
7. 7
   ろ過filtered
8. 8
   濃縮concentrated
9. 9
   その他The resulting crude product was purified by recycle preparative HPLC (HPLC apparatus

実験手順

242 mg (corresponding to 1.0 mmol) of 2-(4′-hydroxyphenyl)-6-methoxyimidazo[1,2-a]pyridine that was sufficiently dried to remove moisture was dissolved in 10 L of N,N-dimethylformamide, and 418 mg (corresponding to 3.0 mmol) of potassium carbonate was added thereto. The mixture was supplemented with 140 μL (corresponding to 1.5 mmol) of 1-bromo-3-fluoropropane, and then was stirred at room temperature for 18 hours. After the completion of the reaction, the reaction solution was poured into water and extracted three times with chloroform. The combined chloroform layer was washed once with water and once with a saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered and concentrated. The resulting crude product was purified by recycle preparative HPLC (HPLC apparatus: LC-908 (under trade name: manufactured by Japan Analytical Industry Co., Ltd.); column: two JAIGEL 2H (under trade name; manufactured by Japan Analytical Industry Co., Ltd.) connected together; mobile phase: chloroform), to obtain 189 mg (corresponding to 0.63 mmol) of 2-[4′-(3″-fluoropropoxy)phenyl]-6-methoxyimidazo[1,2-a]pyridine (hereinafter referred to as Compound 1) (FIG. 2, Step 6).

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