反応 #2146678

反応方程式

4-Acetylpyridine

p-toluene sulfonic acid methyl ester

→

4-acetyl-1-methylpyridinium p-toluene sulfonate

溶媒

ethanol

反応条件

後処理

1. 1
   温度under reflux for 5 hours
2. 2
   その他The solvent was removed under vacuum in a rotary evaporator
3. 3
   その他After separating off the ether phase
4. 4
   その他the product slowly crystallized out
5. 5
   その他The product was dried under vacuum

実験手順

4-Acetylpyridine (30.0 g, 0.25 mol) and p-toluene sulfonic acid methyl ester (55.8 g, 0.30 mol) in 500 ml ethanol were heated under reflux for 5 hours. The solvent was removed under vacuum in a rotary evaporator and the residue was taken up in ether. After separating off the ether phase, the product slowly crystallized out. The product was dried under vacuum. Yield: 59.9 g (82.5%);

出典