反応 #214478

反応方程式

L-Cysteine

2-methyl-2-(methylthio)propanoyl chloride

hydrochloric acid

→

titled compound

収率 89.8%

N-[2-Methyl-2-(methylthio)propanoyl]-L-cysteine

収率 89.8%

溶媒

potassium carbonate

反応条件

後処理

1. 1
   workup.ADDITIONAfter the addition
2. 2
   workup.STIRRINGthe mixture is stirred overnight at room temperature
3. 3
   その他the obtained crystals are separated by filtration
4. 4
   その他dried

実験手順

L-Cysteine (7.1 g) is dissolved in 88 ml of 2 M potassium carbonate and 7.5 g of 2-methyl-2-(methylthio)propanoyl chloride [b.p. 78° C. (37 mmHg)] is added dropwise while stirring under a nitrogen atmosphere at 0° C. After the addition, the mixture is stirred overnight at room temperature. The mixture is acidified with hydrochloric acid and the obtained crystals are separated by filtration and dried to yield 10.4 g (89.8%) of the titled compound.

出典