反応 #214315

反応方程式

2-Bromo-1,1-dimethoxyethane

1,3-butanediol

Toluene sulfonic acid

→

2-bromomethyl-4-methyl-1,3-dioxane

反応条件

後処理

1. 1
   その他fitted with a mechanical stirrer
2. 2
   温度thermometer, Dean Stark trap and reflux condenser
3. 3
   温度the reaction mixture is heated
4. 4
   その他alcohol removed
5. 5
   workup.ADDITIONtreated with sodium carbonate (5 grams)
6. 6
   ろ過filtered
7. 7
   その他a rotary evaporator

実験手順

2-Bromo-1,1-dimethoxyethane (0.1 mole) and 1,3-butanediol (0.1 mole) are charged into a glass reaction vessel fitted with a mechanical stirrer, thermometer, Dean Stark trap and reflux condenser. Toluene sulfonic acid (0.1 grams) is added and the reaction mixture is heated and alcohol removed. When alcohol evolution ceases, the reaction mixture is then cooled to room temperature, treated with sodium carbonate (5 grams) and filtered. Volatiles are stripped from the filtrate using a rotary evaporator to yield the desired product 2-bromomethyl-4-methyl-1,3-dioxane as the residue.

出典