反応 #214283

反応方程式

thiourea

sodium bicarbonate

3-carbamoyloxymethyl-7-(3-oxo-4-bromobutyramido)-3-cephem-4-carboxylic acid

→

3-carbamoyloxymethyl-7-(2-aminothiazol-4-yl)acetamido-3-cephem-4-carboxylic acid

収率 92.1%

溶媒

tetrahydrofuran

water

反応条件

後処理

1. 1
   workup.STIRRINGthe resulting solution was stirred for 40 minutes at room temperature
2. 2
   その他After the reaction
3. 3
   ろ過the precipitated crystals were collected by filtration with suction
4. 4
   洗浄washed with water, tetrahydrofuran and water in turn
5. 5
   乾燥dried over phosphorus pentoxide

実験手順

To a solution of thiourea (0.103 g.) and sodium bicarbonate (0.11 g.) in a mixture of tetrahydrofuran (1.3 ml.) and water (1.3 ml.) was gradually added 3-carbamoyloxymethyl-7-(3-oxo-4-bromobutyramido)-3-cephem-4-carboxylic acid (0.55 g.) with stirring at room temperature, and then the resulting solution was stirred for 40 minutes at room temperature. After the reaction, the precipitated crystals were collected by filtration with suction, washed with water, tetrahydrofuran and water in turn, and then dried over phosphorus pentoxide to give 3-carbamoyloxymethyl-7-(2-aminothiazol-4-yl)acetamido-3-cephem-4-carboxylic acid (0.48 g.).

出典