反応 #214122

反応方程式

4-(hexadecylamino)benzoic acid

lactic acid

toluenesulfonic acid

→

1-carboxyethyl 4-(hexadecylamino)benzoate

溶媒

toluene

反応条件

後処理

1. 1
   workup.ADDITIONA flask containing 10.0 g
2. 2
   workup.ADDITIONcharged
3. 3
   温度The solution is refluxed for 24 hours, during which time the Soxhlet extractor
4. 4
   workup.ADDITIONis charged twice more with fresh sieves
5. 5
   ろ過The hot solution is filtered
6. 6
   workup.WAITleft
7. 7
   温度to cool, whereupon the product

実験手順

A flask containing 10.0 g. (27.7 m moles) 4-(hexadecylamino)benzoic acid, 3.3 g. (36 m moles) lactic acid, 500 mg. toluenesulfonic acid and 500 ml. toluene is equipped with a Soxhlet extractor charged with activated 4 A Linde molecular sieves. The solution is refluxed for 24 hours, during which time the Soxhlet extractor is charged twice more with fresh sieves. The hot solution is filtered and left to cool, whereupon the product separates as off-white crystals.

出典